The immune system is the collective army of a trillion white blood cells, the bone marrow, antibodies, cytokines and the thymus gland that help to identify and destroy the millions of microbes (bacteria, viruses, parasites, fungi) that penetrate our bodies every day, and the thousands of our own cells that have become genetically abnormal or cancerous.

HIV (AIDS) and hepatitis are among the most common viral diseases today. NK (Natural Killer) cells, one of the most important fighters of the immune system, are our cells capable of killing cancerous and virus-infected cells. A single NK cell, which makes up about 10% of lymphocytes in the blood and has a life of about 2 weeks, can repeat this activity 27 times throughout its life. In cases of stress or illness, the immune system may not work with all its effectiveness. Preservation of the number and activity of NK cells, T and B lymphocytes in these conditions is very important.

Studies with Bi.Bran (Arabinoxylan MGN-3) have found that this component, which is known to be absorbed directly in the digestive tract, entering the blood stream, shows its effect in a short time. Although its mechanism of action has not been fully explained yet, it activates the Natural Killer Cells, T cells, B cells, and macrophages, either directly in the blood, or indirectly via the Peyer's patch of the ileum and plays an important role in immunomodulation (immunostimulation, anti-inflammation, anti-allergy, antioxidation processes). One of the accepted mechanisms of action is that the low molecular weight of Arabinoxylan MGN-3 has a positive effect on its uptake by M (Microfold) cells in Peyer's patch. In addition, low molecular weight arabinoxylans can be directly transferred from the intestinal wall to the blood circulation system and can be transported to immune system cells in lymph nodes. (1)

A laboratory study showed that rice bran arabinoxylan compound decreased HIV-1 replication in a dose-dependent manner. (2) Rice bran arabinoxylan compound (Arabinoxylan MGN-3), which has been found to increase NK cell activity and phagocytic activity of macrophages, has also been investigated for immune functions in HIV + patients. In a double-blind study initiated in 2015 at the University of Miami, 47 AIDS patients were blindly radomized into two groups. Viral load of patients was recorded at the beginning of the study. Patients in the MGN-3 group received 3 grams Arabioxylan MGN-3 per day for 6 months and patients in the control group received only placebo capsules containing 3 grams cellulose per day for 6 months. Evaluations were made at the beginning of the study, at the end of the 3rd month and at the end of the 6th month. An improvement in CD4 + / CD8 + rates was detected in the group using MGN-3 compared to the placebo group. The study showed that the rice bran arabinoxylan compound (Arabinoxylan MGN-3) is a compound that can delay disease progression in HIV + patients. (3)

In a randomized clinical trial, investigating the effectiveness of rice bran arabinoxylan in chronic hepatitis C infection, 37 chronic hepatitis C patients were divided into two groups to use pegylated interferon + ribavirin treatment or Arabinoxylan MGN-3. At the end of the study, it was observed that the Arabinoxylan MGN-3 gave similar results to pegylated interferon + ribavirin treatment without any side effects, and it was stated to be a safe and cost-effective option. (4)


1. Ghoneum M. 1998. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran. Biochem Biophys Res Commun. 243(1):25–29.

2. GHONEUM, M. & MATSUURA, M. 2004. Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). International journal of immunopathology and pharmacology, 17, 283-292.

3. John E. Lewis, Steven E. Atlas, Muhammad H. Abbas, Ammar Rasul, Ashar Farooqi, Laura A. Lantigua, Frederick Michaud, Sharon Goldberg, Lucas C. Lages, Oscar L. Higuera, Andrea Fiallo, Eduard Tiozzo, Judi M. Woolger, Stephanie Ciraula, Armando Mendez, Allan Rodriguez & Janet Konefal (2018): The Novel Effects of a Hydrolyzed Polysaccharide Dietary Supplement on Immune, Hepatic, and Renal Function in Adults with HIV in a Randomized, Double- Blind Placebo-Control Trial, Journal of Dietary Supplements

4. Salama, H., Medhat, E., Shaheen, M., Zekri, A. N., Darwish, T., & Ghoneum, M. (2016). Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. International journal of immunopathology and pharmacology, 29(4), 647–653.